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This article needs to be updated. Please update this article to reflect recent events or newly available information. Acute ;rom leukemia was first characterized in 1957 by French and Norwegian physicians as a hyperacute fatal illness, with a median survival time of less than a week. Today, prognoses have drastically improved; 10-year survival rates are estimated to be approximately 77% according to one study. This mutation involves a translocation of the long arm of chromosomes 15 and 17. Presence of multiple on peripheral blood smear is highly suggestive of flow promyelocytic leukemia. As of 2013 the program of treatment for concurrent chemotherapy has becomebefore 2013 the standard of treatment was e. Both chemotherapies result in a clinical remission in approximately 90% of patients with arsenic trioxide having a more prpm side effect profile. This is associated with the development offever, weight gain, peripheral and is treated with. The etiology of retinoic full syndrome has been attributed to capillary leak syndrome from cytokine release from the differentiating promyelocytes. It produces less cardiotoxicity than anthracycline-based treatments and hence may be preferable in pro patients. A prom portion of patients will relapse without consolidation therapy. Remission with arsenic prom has been reported. Arsenic also increases caspase activity which then induces. It does reduce the relapse rate for high risk patients. Prognosis is generally good relative to other leukemias. Because of the acuteness of onset compared to other leukemias, early death is comparatively more common.

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